In Secret of Mana, Mushbooms are encountered at the surrounding areas of Potos and Pandora and later at Gaia's Navel. Mushbooms are stronger than in Final Fantasy Adventure, and can perform a few attacks, which includes kicking, spinning on their cap, and opening up their back to release spores, which can inflict Sleep on their target. Mushrooms are a part of the Tree Group.
There is a town named Matango that is solely inhabited by friendly Mushbooms, all of whom have differently colored mushroom caps than the enemies themselves. Their area is ruled over by King Truffle.